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CNSLF Bone Path 1&2 (v) - Bone tumours 2 (Ewing's sarcoma…
CNSLF Bone Path 1&2 (v) - Bone tumours 2
Giant cell tumours (osteoclastoma)
adults 20-55
epiphyseal ends of long bones (knee, distal femur, proximal tibia)
stromal cells + multinucleated osteoclast-like giant cells
soap bubble appearance on x-ray
locally aggressive (50% recurrence if curetted)
4% are malignant + met
Ewing's sarcoma
malignant prolif of poorly differentiated cells derived from neuroectoderm
children + YAs
sites = medulla cavity in diaphysis of long bones, pelvis, ribs
chromo translocation - t(11;22)
small round blue cells
x-ray onion skin
highly aggressive
tx - chemo
combo of chemo + surgery increases survival from 5% -> 75%
prognosis = v poor
under 10% 5 yr survival with surgery + radio
40% 5-yr survival with adjuvant chemo