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CNSLF Bone Path 1&2 - Metabolic Bone Disease, Fractures & Tumours…

- - - - heterozygotes have normal longevity
      - homozygotes die shortly after birth
  - - - neutropenia (infections)
      - anaemia
      - hepatosplenomegaly due to extramedullary haematopoiesis (generation of BM elements in liver + spleen)
- - - - bone is cracked but not broken into 2 pieces
      - in young immature bone (children)
      - heal the most rapidly
    - - skin is broken + bone may protrude through
      - risk of infection as communicates with the overlying skin
    - - bone is splintered/shattered
      - multiple bone fragments @ site of fracture (which must be reabsorbed - thus delayed healing)
    - - osteoporosis
      - osteomalacia
      - Paget's
      - tumours - primary or mets
      - congenital bone disorders