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Other Psychiatric Drugs (Lithium (MOA Mood stabiliser, Toxicity
Coarse…
Other Psychiatric Drugs
Lithium
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Toxicity
- Coarse tremor
- Cerebellar signs
- AKI
- Hyper-reflexia
- Coma
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Toxicity ↑d by
- NSAIDs
- Diuretics (esp. thiazides)
- ACEi / ARB
- ↓ Na
- dehydration
↑ Li reabsorption in renal PCT
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Use
- Acute mania
- Prophylaxis of BAD
- Resistant depression
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Benzodiazepines
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Interactions
levels / fx ↑d by:
- antipsychotics
- azoles
- macrolides
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Phenobarbitol
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Interacts with CBZ, phenytoin
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