Please enable JavaScript.

Coggle requires JavaScript to display documents.

Neuromuscular Junction (background (Which systems are involved in this…

- - - - an initial presenting symptom of tetanus is flaccid paralysis which can resemble the effects of C. botulinum.
        
        when the toxin is transported toward the central nervous system (CNS) and eventually reaching the spinal cord or brainstem.
- - - - This toxin is a poison that blocks the nerve signals from your spinal cord to your muscles.
        
        Hypertonicity and generalized severe muscular spasms develop when the tetanus toxin blocks the release of inhibitory neurotransmitters at the neuromuscular junction.
- - - - The vesicle membrane attaches to the cell membrane.
        
        Fusion of the vesicle membrane with the cell membrane releases the vesicle contents outside the cell.
  - - - Embedded in the end plate are thousands of receptors, which are long protein molecules that form channels through the membrane.
        
        Upon stimulation by a nerve impulse, the terminal releases the chemical neurotransmitter acetylcholine from synaptic vesicles.
        
        Acetylcholine then binds to the receptors, the channels open, and sodium ions flow into the end plate.
        
        This initiates the end-plate potential, the electrical event that leads to contraction of the muscle fiber.
  - - - muscular
    - - muscular
    - - Skeletal
    - - respiratory
    - - nervous/ muscular
  - - - The toxin causes inhibition of the release of GABA and glycine inside inhibitory nerve terminals that control the activity of the lower motor neurons.
        
        hyperactivity effect leading to involuntary contraction of the skeletal muscles.