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Beta Lactams Bactericidal (Cephalosporins (2nd gen Cefuroxime (Mod / sev…
Beta Lactams Bactericidal
Penicllins
Eg
Pen V
Pen G (IV)
Streps
N. meningitidis
Syphilis
Penicillinase-resistant
Fluclox
MRSA?
Anti-pseudomonal
Piperaccillin
Ticarcillin
Pseudomonas
Broad Spectrum
Amoxicillin
Ampicillin
Pneumococcus
Listeria
E. coli
Enterococci
Co-amoxiclav
Severe CAP
UTI
Tazocin
Severe HAP
Sepsis
MOA - Inhibit bacterial transpeptidase enzyme
Required for cell wall construction
SE
Hypersensitivity
Rash
EM
anaphylaxis
GI upset
Mac pap rash with EBV
Interaction
May ↓ fx of OCP
↑d by probenecid
CI
Hypersensitivity
10% x-reactivity
with cephs
Cephalosporins
MOA - Inhibit bacterial transpeptidase enzyme
Required for cell wall construction
Generations have ↑ing activity vs. Gm-ve
2nd gen
Cefuroxime
Mod / sev CAP
GI sepsis
Pre-op
3rd gen
Cefotaxime
Ceftriaxone
Ceftazidime
Cefixime
Meningitis
Epiglottitis
Gonorrhoea
SBP
1st gen
Cephalexin
Cefaclor
UTI
CI Hypersensitivity
SE
GI upset
AAC
Carbapenems
MOA - Inhibit bacterial transpeptidase enzyme
Required for cell wall construction
Imipenam
Meropenam
Ertapenam
Imipenem is rapidly inactivated by the kidney and must be given with cilastatin which blocks its metabolism
All Gm+ except MRSA
Most Gm-ves
Neutropenic sepsis
V. broad spectrum
Gm-, Gm+ and anaerobes
Pseudomonas
SE GI upset