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Inhibitors of Protein Synthesis (Oxazolidinones Bacteristatic 23s…
Inhibitors of Protein Synthesis
Oxazolidinones
Bacteristatic
23s component of 50s
subunit
Linezolid
Use
MRSA and VRE
No activity vs. Gm-
SE Blood dyscrasias
Caution in R and L
Macrolides
Bacteriostatic
50s subunit
Erythromycin
Clarithromycin
Azithromycin
Use
Pen allergy
Atypical pneumonia
Chlamydia
H. pylori
SE
↑ QTc
Dry skin
Cholestatic hepatitis
Caution if ↑QTc
Interactions
P450 inhibitor W+
↑ digoxin
Streptogramins
Bacteriostatic
50s subunit
Synercid
Use
VRE
MRSA
Only used when other
agents failed
Lincosamides
Bacteriostatic
50s subunit
Clindamycin
SE
AAC
Hepatotoxicity
Stop drug if pt. develops diarrhoea
Use
Active vs. Gm+ cocci and
bacteroides
Osteomyelitis
MRSA
Tetracyclines
Bacteriostatic
30s subunit
Tetracycline
Doxycycline
Use
COPD exacerbation
Acne
Chlamydia
Rickettsia
Brucella
Lyme disease
SE
GI upset
Hypersenstivity
Bone deposition
CI
Children <12yrs
L
R
Interactions
Toxicity ↑ by
frusemide
cephs
vanc
ciclosporin
Bacteriostatic
50s subunit
Chloramphenicol
Use Conjunctivitis
SE
Irreversible aplastic anaemia
Grey baby syndrome
CI P L R
Aminoglycosides
Bactericidal
Amino-acyl site of 30s
subunit
Gentamicin
Amikacin
Tobramycin
Neomycin
Streptomycin
Use Gm- sepsis
Neutropenic sepsis
Otitis externa
Anti-pseudomonal
SE
Nephrotoxic
Ototoxic
↓ absorption with milk + antacids
CI
Myasthenia gravis
Caution in R - alter dose and time