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Anti-Fungals (Echinocandins (Caspofungin (MOA Inhibit β-glucan synthesis …

- - - - Oral/vag/oesophagus candida
        Alternative to ampho B for systemic
        infections
      - P450 inhibitor
    - - Invasive candida or aspergillus in
        immunocomp
        BMT transplant pt. prophylaxis
      - SE
        Photophobia
        Rash
        Hepatotoxic
    - - Blasto/histo/coccidio
        Sporotrichosis
        Chromomycosis
        Aspergillus
    - - Invasive candida, mucor and
        aspergillus in immunocomps
  - - - Indication:
        Dermatophyte infections
        Mucocutaneous candidiasis
    - - Indication: Chronic mucocutaneaous candidiasis
      - SE: Hepatotoxic
        ↓androgen synthesis
- - - - Indication
        
        Candidiasis: cutaneous, vaginal,
        mucosal, oesophageal
      - Give PO or topical
      - Toxic if given IV
    - - Indication:
        Severe systemic fungal infections (IV)
        
        cryptococcal meningitis
        
        systemic candidiasis
        
        pulm. Aspergillosis
      - Monitor Cr
      - SE
        
        Nephrotoxic (IV)
        
        IV reaction (after 1-3h)
        
        fever
        
        hypotension
        
        nausea/vomiting