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Viral Infections (Influenza (if >1yr old with symptoms of <48hr…
Viral Infections
Influenza
Iniitial
Bed rest + paracetamol
If severe
Mx in ITU
Cipro and co-amoxiclav: prevent Staph and Strep
if >1yr old with symptoms of <48hr
Neuraminidase inhibitor active vs. flu A and B
Oseltamivir
if >5yrs old with symptoms <48h
Inhaled NA inhibitor active vs. influenza A and B
Zanamivir
Herpes Viruses
VZV
Aciclovir
CMV
Ganciclovir / valganciclovir
Foscarnet
Cidofovir
HSV
Aciclovir
Valaciclovir
Famciclovir
Hepatitis
HBV
Combination or individual use of
Peg-interferon-α
Tenofovir
Entecavir
HCV
Peg-interferon-α + ribavarin
HIV
Regimens
1 NNRTI + 2 NRTIs
NNRTI = efavirenz
NRTI = emtricitabine + tenofovir (Truvada)
Atripla = efavirenz + emtricitabine + tenofovir
PI + 2 NRTIs
PI = lopinavir
lopinavir + low dose ritonavir = Kaletra
Aim
Undetectable VL after 4mo
If VL remains high despite good compliance
Change to a new drug combination
Request resistance studies
Indications
CD4 ≤350
AIDS-defining illness
Pregnancy
HIVAN
Co-infected with HBV when Rx is indicated for HBV