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T2DM TX (Additional Therapy (2nd line (Add sitagliptin or pioglitazone if…
T2DM TX
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- Metformin + Sulfonylurea
(if HBA1c >target)
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SE: hypoglycaemia, wt. gain
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Other Options
Consider adding a rapid-acting insulin secretagogue (e.g. nateglinide) to metformin instead of a sulfonylurea.
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- Lifestyle Modification: DELAYS
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- Start Metformin
(if HBA1c >target after lifestyle changes)
SE: nausea, diarrhoea, abdo pain, lactic acidosis
CI: GFR<30, tissue hypoxia (sepsis, MI), morning before GA and iodinated contrast media
500mg after evening meal, ↑ing to 2g max.