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Insulin (Effects of insulin (Adipose tissue ((↑ lipoprotein lipase…

- - - - ↑ lipoprotein lipase activity → ↓ TGs
      - ↑ GLUT-4 activity → ↑ glucose storage as fat
      - ↓ lipolysis → ↓ fatty acids release into circulation
  - - - ↓ glycogenolysis
      - ↓ gluconeogenesis
        
        ↑ glycogenesis
      - Inhibition of ketogenesis
  - - - ↓ proteolysis
      - ↑ GLUT-4 activity → ↑ glucose uptake
- - - - 2-4 hrs
    - - 6-8 hrs
    - - 30-60 mins
  - - - 1-3 hrs
    - - 2-5 hrs
    - - 15 min
- - - - 12hrs
  - - - Glargine: 24hrs
        Detemir: 20hrs
- - - - IV: 1min peak conc
      - SC: 90min peak conc
- - - - DKA
      - Control in critical illness
      - Control in peri-operative period