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Inhibitors of Cell Signalling (MOA (Calcineurin inhibitors Blocks IL-2…
Inhibitors of Cell Signalling
MOA
Calcineurin inhibitors
Blocks IL-2 production
Ciclosporin
SE
Hepatic dysfunction
Tremor
Hypertrichosis
Gingival hypertrophy
Encephalopathy
Nephrotoxic
Interactions
P450 metabolism
use
GvHD
UC
RA
Psoriasis
Prevent Tx rejection
Monitor LFTs
Tacrolimus
SE
Nephrotoxic (< cf. ciclosporin)
Diabetogenic
Neurotoxic (> cf. ciclosporin)
interactions
P450 metabolism
use
Prevent Tx rejection
MOA
Blocks mTOR pathway
Sirolimus
SE
Dyslipidaemia
Use
Prevent Tx rejection