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Severe face and muscle spasms, inability to speak (Systems Involved…
Severe face and muscle spasms, inability to speak
If left untreated, can lead to respiratory failure and death
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Clostridium Tetani
Tetanospasmin is a neurotoxin that inhibits the release of γ-aminobutyric acid (GABA) and results in muscle spasms and rigidity, lockjaw, dysphagia, tendon rupture, opisthotonus, respiratory difficulty, and death
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Twitch- short, sudden convulsive movement
Neuromuscular Junction
Arrival of action potential causes depolarization of the terminal that opens calcium channels, allowing calcium influx
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