Severe face and muscle spasms, inability to speak

If left untreated, can lead to respiratory failure and death

Infected with Clostridium tetani (which affects neurons) because he wasn't vaccinated

Got tattoo from sketchy parlor

Systems Involved

Muscular

Nervous

Respiratory

Circulatory

Clostridium Tetani

Tetanospasmin is a neurotoxin that inhibits the release of γ-aminobutyric acid (GABA) and results in muscle spasms and rigidity, lockjaw, dysphagia, tendon rupture, opisthotonus, respiratory difficulty, and death

Exocytosis

Muscle Contractions

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Summation-Additive effet of several electrical impulses on a neuromuscular junction

Tetany-Intermittent muscle spasms

Twitch- short, sudden convulsive movement

Neuromuscular Junction

Vesicle is transported to the cell membrane

Vesicle membrane fuses with the cell membrane and releases the contents from the cell

Cell forms vesicle around material that needs to be expelled from the cell

Arrival of action potential causes depolarization of the terminal that opens calcium channels, allowing calcium influx

Calcium influx

Lactic acid

ATP

Glucose