Serotonin - In normal levels this exerts a calming, inhibitory effect gonna neural firing in the brain. Serotonin typically inhibits the firing of the amygdala, the part of the brain that controls anger, fear and other emotional responses. Low levels of serotonin remove this inhibitory effect, with the consequence that individuals are less able to control impulsive and aggressive behaviour. As a result, when the amygdala is stimulated by external events, it becomes more active, causing the person to at on their impulses, and making aggression more likely. Serotonin is also thought to reduce aggression by inhibiting responses to emotional stimuli that might otherwise lead to an aggressive response. Low levels of serotonin in the brain have been associated with an increased susceptibility to impulsive behaviour, aggression and even violent suicide. Some drugs are though too alter serotonin levels and thus increase aggressive behaviour. Mann et al (1990) gave 35 healthy participants dexfenfluramine, which is known to deplete serotonin. Using a questionnaire at access hostility and aggression levels, they found that dexfenfluramine treatment in males (but not females) was associated with an increase in hostility and aggression scores