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Neuromuscular Junction (if left untreated (respiratory issues may occur…

- - - - Acetylcholine
    - - voltage gated ion channels open on the axon terminal to allow Ca ions into the synaptic bulb
      - action potential depolarizes the axon terminal
      - Neurotransmitter is in a synaptic vesicle
      - Calcium triggers the exocytosis of synaptic vesicle contents
  - - - A motor units response to a single action potential of the motor neuron
    - - successive stimuli (action potential) are added together to produce a stronger muscle contraction
    - - fusion of contractions to produce a continuous contraction
  - - - tetanolysin
        
        causes local tissue destruction
      - tetanospasmin
        
        causes clinical tetanus
        
        Made of 2 chains joined by a disulfide bond
        
        heavy chain binds to neuronal cells (disialogangliosides)
        
        light chain (zinc endopeptidase), blocks the release of inhibitory neurotransmitters (GABA & Glycine)
        
        blocks inhibitor from blocking ACh
        
        nothing stops the release of acetycholine from the excited neuron
        
        Muscle stays contracted