23 year old man brought in to ER by brother hardly speaking having muscle spasms and has fresh tattoo on shoulder and began having symptoms the next day.
Background
Clostridium Tetani
LockJaw
Affects brain and nervous system
Muscular System
Respiratory system
Excretory System
Neuromuscular Junction
Transmits a signal to the muscle fiber, causing muscle contraction.
nerve meets axon of motor neuron and releases ACH
Upstream
Flaccid Paralysis
Downstream
can lead to muscle rigidity.
ACH diffuses, binds to receptor,triggers muscle action potential
release of ach quantam
ap to t tubule opens ca2 enters into sarcoplasm
CA2 binds to troponin
contractions
Ca2 channel close calcium pumps use atp to restore Ca2 levels
troponin returns to original position stops myosin binding
muscle relaxes
Neurotransmitters
acetylcholine
exocytosis
vesicle trafficking
tethering
docking
priming
fusing
muscle twitch
single contraction that last fraction of a second
Summation
increases force of contraction increasing frequency of muscle fibers
Tetanus
fusion of a contraction to produce continuous contraction
Clostridium Tetani
Tetanolysin
Tetanospasmin
not none with certainty
causes tetanus
muscles cannot contract at all
Tetany
electrolyte imbalance
balance
trouble swallowing
droopy eyelids
patient received tattoo at a sketchy tattoo parlor
convulsions
death