23 year old man brought in to ER by brother hardly speaking having muscle spasms and has fresh tattoo on shoulder and began having symptoms the next day.

Background

Clostridium Tetani

LockJaw

Affects brain and nervous system

Muscular System

Respiratory system

Excretory System

Neuromuscular Junction

Transmits a signal to the muscle fiber, causing muscle contraction.

nerve meets axon of motor neuron and releases ACH

Upstream

Flaccid Paralysis

Downstream

can lead to muscle rigidity.


ACH diffuses, binds to receptor,triggers muscle action potential

release of ach quantam

ap to t tubule opens ca2 enters into sarcoplasm

CA2 binds to troponin

contractions

Ca2 channel close calcium pumps use atp to restore Ca2 levels

troponin returns to original position stops myosin binding

muscle relaxes

Neurotransmitters

acetylcholine

exocytosis

vesicle trafficking

tethering

docking

priming

fusing

muscle twitch

single contraction that last fraction of a second

Summation

increases force of contraction increasing frequency of muscle fibers

Tetanus

fusion of a contraction to produce continuous contraction

Clostridium Tetani

Tetanolysin

Tetanospasmin

not none with certainty

causes tetanus

muscles cannot contract at all

Tetany

electrolyte imbalance

balance

trouble swallowing

droopy eyelids

patient received tattoo at a sketchy tattoo parlor

convulsions

death