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Week 3: Nucleic Acids (Appliciations (Amplify DNA using PCR* Polymerase…

- - - - Generate exponential number of
        copies from original template DNA.
- - - - Ribose: with 2`Hydroxy
      - Deoxyribose: with 2`Deoxy
    - - Purines
        
        Adenine
        
        A:T
        
        Guanine
      - Pyrimidines
        
        Uracil Occurs in RNA
        
        A:U
        
        Cytosine
        
        G:C complementary pairs are
        MORE STABLE than A:T or A:U.
        
        Thymine Occurs in DNA
      - Purines and pyrimidines connect via hydrogen bonds
    - - Absent in Nucleosides: only sugar and base
  - - - Base-pairing leads to helical secondary structure
      - Double-stranded – two DNA strands Intertwined together
      - The major and minor grooves of DNA are places where we design chemical drugs to bind.
        
        That will prevent the DNA from unwinding and replicating , which we don’t want in cancer cells.*
    - - Single-stranded
      - Base-pairing leads to stem-loop secondary structure