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Neuromuscular Junction (Painful muscle spasms in face and arm (lockjaw…
Neuromuscular Junction
Painful muscle spasms in face and arm
lockjaw
spasms are uncontrollable
changes in blood pressure and heart rate
possible complications such as pulmonary embolism
difficulty swallowing
possible fever
muscles become stiff
uncontrolled tightening of vocal cords
blocks the release of neurotransmitters
disinhibition of lower motor neurons
respiratory system could possibly fail
Infection via dirty needle
Wasn't vaccinated
Background
Nervous System affected
muscular system affected
circulatory system affected
skeletal system affected
respiratory system affected
Acetycholine binds to receptors on outside of muscle cell fiber causing contraction
calcium binds to troponin
tropomyosin rotates off the binding sites for myosin
myosin binds to actin
myosin pulls actin towards center of sacromere
twitch is rapid and brief muscle spasm
tetany is prolonged contraction without relaxation
Summation is repeated stimulation of muscles after they have been relaxed
tetany usually involves hands, feet, and mouth/face
Neuromuscular Junction
Action potential arrives at axon terminal
Voltage gated CA2+ channels open
CA2+ causes ACH to be released via exoctyosis
ACh diffuses across synaptic cleft and binds to ACH receptors in sacrolemma
ACh binding opens chemically gated ion channels
Na+ and K+ pass in and out of muscle fiber simultanously
local change in the membrane potential occur called end plate potential
Exocytosis
molecules within the cell are transported to cell membrane
vesicle membrane attaches to cell membrane
fusion of vesicle membrane and cell membrane release vesicle contents outside the cell
CA2+ enters the axon terminal
muscle spasm occurs in face and arms
possible lockjaw but not tetany