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Neuromuscular Junction: Tattoo incident (Anatomy (4 systems (integumentary…
Neuromuscular Junction: Tattoo incident
guy got a tattoo from a sketchy parlor and started getting spasms(direct)
Anatomy
4 systems
integumentary
muscular
nervous
respiratory
neuromuscular junction
axon terminal
synaptic vessicles
acetylcholine
ligand gated
membrane potential
t-tubles
troponin
1 more item...
neurotransmitters
acetylcholine
exocytosis
difference
summation
tetany
twitch
Clostridium tetani
Physiology
4 systems
integumentary
site of cutanoeus receptors
when the needle went into the skin thats how the toxin made it inside
muscular
body movement
toxin blocks the zap, so muscle can not contract.
nervous
sends signals to muscles
when zap meets NMJ the toxin blocks the zap
respiratory
breathing
diaphragm(is a muscle)
if the toxins spreads to the diaphragm, the diaphragm will not contract and can stop breathing.
neurotransmitters
acetylcholine
is in synaptic vesicles
calcium will endocytosis and will make ach exocytosis across synaptic cleft and bind onto acetylcholine receptors
to open ligand gated channel and down sarcolemma
neuromuscular junction
axon terminal
receives the signal from nervous system
the zap
synaptic vesicle
sacs inside of axon terminal
hold ach
acetylcholine
cal will enter axon terminal making ach exocytosis
ach will go across synaptic cleft
land on acetylcholine receptors
ligand gated
when ach lands on receptor, it opens the gate
sodium enter muscle fiber
will cause domino effect on voltage channels down sarcolemma
membrane potential
t-tubles
once action potential is here a voltage channel open letting calcium out
1 more item...
troponin
2 more items...
-70mv to -40mv
depolarization
difference
twitch
is one isolated contraction
cal binds with troponin, tropomyosin lifts of actin binding sites
cross bridges form, scaromere shortens
ex: eye twitching
latent period
action potential propagated along sarcolemma
relaxation phase
Cal are pumped out of sarcoplasm
cross bridge stops
summation
if two stimuli are received by a muscle in rapid succession
when extra stimuli is there before relaxation
stimulus more frequent than a twitch
Ex: push ups or lifting weights(reps)
tetany(fused tetanus)
when stimuli reaches maxium
no relaxation between stimuli
referred to fused cause contractions fuse into one smooth contraction
when relaxation disappears, contractions become continuous
Ex: Grocery bag analogy
clostridium tetani
tetanospasmin(toxin)
if deposited into a wound, it interferes with nerves that control muscle movement
blocks the release of neurotransmitters
exocytosis
vesicles fusing with the plasma membrane
then releasing their contents once outside of cell
other effects of clostridium tetani
fever
sensitivity to touch
rapid heart beat
diarrhea
why spasms
he is only receiving spasms because only a single stimuli(one zap) is breaking through the toxin.
if the toxin is not treated for, the toxin can spread to the diaphrgam and will stop it from contracting, making the patient not being able to breathe.