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Mast Cells (Synthesise inflammatory mediators (Cytokines (IL-3, IL-5, GM…
Mast Cells
Line body surfaces
Mucosal Tissues
Epithelial Tissues
Alert immune system to local infection
Structure
Granular cytoplasm
Contains preformed effector molecules
Granule Contents
Enzymes
Tryptase
Carboxypeptidase
Histamine
Heparin
Synthesise inflammatory mediators
Leukotrienes
PAF
Cytokines
IL-3
IL-5
GM-CSF
IL-4
IL-13
Functions
Increase flow of lymph
To regional lymph nodes
Recruit additonal effector cells and molecules
Trigger muscle contraction
Expel pathogen from lungs/GI Tract
Explusion of paracites
In allergy:
Provoke unpleasant reactions to innoculous antigens
Response depends on tissue type
Link to Eosinophils
Degranulation
Th2 Activation
Promote Eosinophil accumulation and activation