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8 year old with broken radius. Diagnosed with Duchenne Muscular Dystrophy
8 year old with broken radius. Diagnosed with Duchenne Muscular Dystrophy
anatomy
muscle tissue
cardiac muscle tissue
smooth muscle tissue
skeletal muscle tissue
muscle fiber types
glycolytic fibers
fast:
oxidative fibers
fast
slow
muscle fiber cell
organelles: mitochondria, sarcolemma, sarcoplasmic reticulum
endomysium
epimysium
myofibrils
T-Tubules
sarcomere
bone cells
osteoblasts
osteoclasts
osteocytes
physiology
muscle fibers
glycolytic fibers: create ATP using glycolysis. Makes 2-4 ATP to use
oxidative fibers: create ATP using the electron transport chain. Makes 32 ATP.
muscle tissues
skeletal muscle: movement, posture, heat production
smooth muscle: movement of substances
cardiac muscle: pumps blood
muscle fiber cell
T-Tubules: make sure the membrane potential reaches all of the cell
sarcoplasmic reticulum: stores calcium
epimysium: surrounds entire muscle; connective tissue
endomysium: connective tissue; surrounds individual muscle cell
mitochondria: produces energy in the form of ATP
sarcomere: structural unit of a myofibril. Contains dark fibrous protein called myosin and light protein called actin. On the actin protein, there is a protein called tropomyosin that runs the length of the actin, covering its myosin binding sites. Another protein troponin is on the tropomyosin and when activated by calcium, moves the tropomyosin off the binding sites.
myofibril: elongated contractile thread in a muscle cell, contracts the muscle
protein synthesis
Transcription: RNA polymerase attaches to the DNA and creates a mirror mRNA strand which then leaves the nucleus of the cell
Translation: the mRNA goes and binds to a ribosome which reads the mRNA codons and tRNA comes and binds to those codons and releases the correct amino acid onto a chain that builds up and becomes the protein. When translation is finished, protein detaches from ribosome and folds into its secondary and tertiary structures.
The Cross-Bridge Cycle
1: Cross-Bridge Formation
After troponin binds with calcium and moves off the binding sites, an energized myosin head attaches to the actin protein, forming the "cross bridge".
2: Power Stroke
The ADP and Phosphate are released from the myosin head as it bends, changing to a low-energy state and also moving the actin protein towards the M-line in the sarcomere.
3: Cross-Bridge Detachment
ATP binds to the myosin head, and the link is severed between myosin and actin, head detaches.
4: Cocking of Myosin Head
ATP has been used up and hydolizes into ADP and a Phosphate again. The head returns to its high-energy position.
bone cells
osteoblasts: build bone tissue with calcium and phosphates. Influenced by hormones such as estrogen.
osteoclasts: break down bone tissue
Upstream Causes
Duchenne Muscular Dystrophy
Direct Cause
A gene in the X chromosome is mutated and causes alterations in the protein dystrophin, making it more absent. This causes the muscle cells to be fragile and damage easily.
Indirect Cause
Random genetic mutation..
Fall/Fracture
Indirect Cause
Not enough calcium in diet, lack of exercise
Direct Cause
Tripped climbing down the stairs. Not engaging in physical activity because claims to be too tired. Walking on his tiptoes, and struggles to get out of bed in the morning
Downstream Causes
Spine
Scoliosis: curvature of the spine
Muscle and Tendons
Contractures: shortening and hardening of muscle and tendons. Leads to rigid joints and deformity.
Muscle cramps
Fatigue
Muscle Weakness: begins in legs and pelvis, but also in the arms, neck, and other areas. Gradually gets worse.
Motor skills issues (running, jumping)
Falling
Difficulty walking: may lose ability to walk by age 12
Brain and Nervous System
Headaches
Learning and memory problems
Sleepiness
Trouble concentrating
Respiratory
Weakening of respiratory muscles: causes shortness of breath
Heart
Weakening of heart muscle: causes swelling of feet, shortness of breath, fatigue
Heart disease (cardiomyopathy)