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Clostridium tetan (Change in the body (Headache, Rapid heart bea, High…

- - - - ACh acts on nicotinic receptors at the neuromuscular junction.
    - - Binding of GABA to its receptors activates secondary messengers and opens potassium channels. and increasing membrane potential (IPSP)
    - - Muscle spasms
    - - Unipolar neuron
      - Bipolar neuron
      - Multipolar Neuron
    - - Temporal summation
        
        One neuron send multiple message
      - Spatial summation
        
        More than one neuron send message
  - - - Retrograde transport across alpha motor neuron
      - Binding to inhibitory neuron membrane
      - Ganglioside-recognition domain in the heavy chain C-terminal
      - Negatively charged presynaptic membrane of the peripheral nerve terminals
      - Translocation of toxin into the cytosol
- - - - Infection occurs by contaminated wounds
        
        Infection with
        
        Anaerobic, Gram positive soil bacterium, Bacillus
        
        Clostridium tetani