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Immunodeficiency (Primary - 9 classes, 120 conditions (Combined T & B…

- - - - Lymphocytes
      - NK cells
      - Monocytes CD15
      - Activation markers HLA-DR. CD25, CD80
      - T cell function
      - B cell function
      - Phagocyte function
- - - - HSC (hematopoietic stem cells) decline
      - Phagocyte number/ function decline
      - NK activity decline
      - APC (antigen presenting cells) decline
      - B-cell reduction
      - Ab diverse and affinity reduction
      - Reduced naive lymphocytes
      - Reduced memory cell competence
      - Antagonistic pleiotrophy - Inflammation