Please enable JavaScript.
Coggle requires JavaScript to display documents.
kidney's role in homeostasis (removal of toxic waste (excrets urea…
kidney's role in homeostasis
maintenance of electrolyte balance
sodium is freely filtered by glomerular capsules and reabsorbed by distal convoluted tubule
excess water in the body causes hyponatremia
excess water loss causes in hypernatremia
imbalance of ADH and ALDOSTERONE causes
hypernatremia
potassium is excreted both actively and passively by tubules
aldosterone helps to control potassium level
rise in aldosterone affects in secretion of potassium in to the urine by distal tubule
phosphate is important to maintain plasma PH
If plasma phosphate is low then filtered phosphate is reabsorbed in early proximal tubule
if plasma phosphate is high it is excreted by kidney in urine
magnesium is involved in energy storage and production
increase in PTH causes tubular reabsorption of magnesium
removal of toxic waste
excrets urea (waste produced from protein
excrets creatinine generated from muscle
kidney acts as bod's main excretory organ
excrets uric acid ( products of purine)
excrets bilirubin from hemoglobin
mostly drugs are detoxified in liver and excrets through kidney
regulation of body fluid volume
aldosterone is a steroid hormone secreted from the adrenal cortex of the kidney
more aldosterone is secreted more sodium is reabsorbed ,hence more water is reabsorbed
ANP is secreted by cardiac atrial cells in response to stretch in atrium from fluid overload
ANP inhibits aldosterone secretion,reduce renin release ,reduce ADH and reduce the fluid volume by excreting sodium and water
acid base balance
kidney uses carbonic anhydrase to speed up the reactions involving HCO3-
by excreting hydrogen ions in to te urine
kidney helps to keep the body PH within the range of 7.35 -.7.45
by recovering and regenerating bicarbonate from urine
regulation of blood pressure
kidney excrets extra fluid from the body and controls blood pressure
kidney releases enzyme renin which helps to regulate blood ressure
renin converts angiotensinogen to angiotensin 1
ACE helps to metabolise angiotensin | to angiotensin ||
angiotensin || acts directly to the blood vessels and causes vasoconstriction
with the stimulation of angiotensin || aldosterone is produced by adrenal cortex
aldosterone helps in reabsorption of sodium and water and regulates blood pressure
erythropoietin production
epo production is stimulated by hypoxia and controlled by negative feed back principle
erythropoietin maintains normal blood cell count and prevents anemia
epo is a hormone produced by peritubular cells((cortical fibroblasts)
*REFERENCES
https://mcb.berkeley.edu/courses/mcb135e/kidneys.html
https://www.bbc.co.uk/bitesize/guides/zgh2xsg/revision/1
https://search.credoreference.com/
