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Received 8 year old boy at ER due to recent fall resulting in a fracture…
Received 8 year old boy at ER due to recent fall resulting in a fracture to his radius with the history of less physically active and seemed to be more clumsy, walking pattern has changed, now walking on his tiptoes, chef recent complained of muscle aches and weakness and genetic testing confirms that the patient has Duchenne muscular dystrophy.
Upstream causes
Possible direct Causes
Inheritance An X-linked recessive trait, the child's mother is a silent carrier.
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Progressive disorder caused byteh absence of the gene required to produce the mm proteins dystrophin and nublin.
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Downstream Effects
Unusual walk and difficulty running, climbing stairs, and getting up from the floor.
Muscle weakness worsens with age and progresses to the arms, legs and trunk.
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Clumsy movement, shoulder arm facial weakness
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Difficulty swallowing, fatigue, scoliosis, or shallow breathing
Anatomy
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Cross Bridges
The 'blob' that link the thin and thick filaments at intervals and stick out from the thick filaments.
Cross Bridge cycle
- The cross bridge swings out from the myosin filament and attaches to the actin filament.
2.The energy from the hydrolysis of ATP is used for the cross bridge changes shape and rotates 45 degrees causing the filaments to slide ('Power Stroke').
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4.The cross bridge changes back to its original shape, so the cycle can begin again further along the actin filament.
Skeletal system, muscular system
The human body is a complex network of symbiotic systems. The skeletal system and the muscular system work together as the framework for the body as well as providing the pieces that allow for movement.
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