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"A way to estimate rate of LDL-c uptake... (Tracers (Radioactive…
"A way to estimate rate of LDL-c uptake...
Tracers
Radioactive tracer
Colorful cholesterol
Color hepatocytes, degrade color upon LDL uptake
Fluorescent tracer
Nanotech
Robotic pill
Robot cholesterol
Nanorobot that sticks to receptor
Light sensitive sensor
Mechanical / Device-based
External
Sleep sensor test
Shoe wearable
App connected to doctor
Smart watch app
Ring sensor (clot/artery)
Blood pressure sensing system
Internal
Heart implant to measure rate of LDL uptake
Temporary implant
Artificial removable vein that collects cholesterol buildup over time
A stent that measures LDL over time
LDL receptor implant to measure rate
Real time blood sensor reader
Molecular
Analyze Body Samples
Harder to Acquire/More Invasive
Plaque buildup on Achilles tendon (tendon xanthomas)
Blood Sample (not hard to acquire, but invasive)
Harvest calcification/plaque on arteries
Easy to Acquire/Non-invasive
Urine
Feces
Sweat
Tears
Skin oil
Retinal exam
Hair
Saliva
Fingernails
Ear wax
Find molecular kinetic constants
Rate of cholesterol binding to LDLR
Rate of LDL uptake into cells
Rate of LDLR recycling to cell membrane
Mathematical/Computational
Prediction formula
What to predict
Likelihood of early cardiac event
Likelihood of cardiac event
Likelihood of FH
Rate of LDL Uptake
Lifetime LDL Exposure
Factors to include in formula
Past Cholesterol Measurements
Body Fat Ratio
BMI
Genetic tests
Family History
Age
Culture Patient Cells (
In vitro
kinetic measurements)
Assays
Measure LDL uptake
Measure LDL degradation
Cell Types
Fibroblasts
hiPSCs
Hepatocytes