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A 12 year old boy brought in with a broken elbow, and part of the bone in…
A 12 year old boy brought in with a broken elbow, and part of the bone in the upper arm appears to be protruding from the skin. Fragments of bone are in the wound.
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Bone Growth
Cells divide quickly, pushing epiphysis away from diaphysis and lengthening entire bone
Older chondroctyes enlarge. Their lacunae erode and enlarge, leaving large interconecting spaces
Surrounding catilage matrix calcifies, chondrocytes die, matrix begins to deteriorate, allowing blood vessels to invade
Calcified spicules are invaded by marrow elements from medullary cavity. Osteoclasts partly erode cartilage spicules, osteoblasts cover them with new bone
Bone Remodeling
Bone Resorption
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Osteoclasts move along a bone surface, digging depressions or grooves as they break down the bone matrix
Osteoclasts cling tightly to the bone, secreting acid, dissolving bone minerals.
The digested matrix end products and dissolved minerals are then endocytosed, transported across osteoclast, and released at opposite side
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When resorption of a given area is completed, osteoclasts undergo apoptosis (cell death)
Bone Depostion
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Calcium salts are deposited throughout the osteoid, creating calcified bone matrix
Control of Remodeling
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Keeping bone strong
Mechanical and gravitational forces acting on a bone drive remodeling where it is required to strengthen that bone
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Location of break
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An epiphyseal fracture could lead to that limb not growing anymore leaving it shorter than the other limb
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