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Aging (physiological changes (cardiovascular system (lose of vascular…

- - - - presbycusis
- - - - senescence theory
        
        reduced telomere length
      - autoimmune theory
      - endocrine theory
- - - - low water soluble drug distribution and high lipid soluble distribution
    - - GIT physiological changes affect absorption of medications such as hypochlorhydria
    - - decreases liver function and hepatic flow lead to decrease drugs metabolism
    - - low renal blood flow, low GFR, low tubular secretion lead to low renal clearance of drugs thus drugs accumulate and increase toxicity