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REGUB: Pathology of the Fallopian Tubes and Ovaries (iv) Ovarian Neoplasms…
REGUB: Pathology of the Fallopian Tubes and Ovaries (iv) Ovarian Neoplasms cntd
mets
clinical hx
gross + microscopic features
Kruckenberg tumours: GI or breast primary
mucinous tumours: usually GI (primary ovarian unlikely)
most are mullerian primaries: uterus, fallopian tube, contralat ovary, pelvis peritoneum
Hereditary cancer syndromes
BRCA
Lynch
Ovarian cancer staging (FIGO)
1: limited to ovary
a: 1 ovary, intracystic
b: both ovaries, intracystic
c: rupture, tumour on surface
2: spread to pelvis
3: spread to abdo/nodes
4: distant spread
high stage = 3+4 (90% are HGSC)
low stage = 1+2
Distribution of invasive ovarian tumours by type
68% = HGSC (high grade serous carc)
11% = endometrioid
12% = clear cell
3% = mucinous
3% = low grade serous carc