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Biotin (Deficiency Causes (decreased absorption (Avidin, Anticonvulsants),…
Biotin
Deficiency Causes
Biotinidase Deficiency
Holocarboxylase Synthase Deficiency
Decreased intake
decreased absorption
Avidin
Anticonvulsants
Antibiotics
Metabolic Role
Glucose metabolism
Pyruvate carboxylase
Deficiency result
Pyruvate + Lactate Buildup
FA Synthesis
Acetyl CoA Carboxylase
Deficiency result
Acetyl CoA Buildup; Ketosis
TCA Cycle
Propionyl CoA Carboxylase
Leucine Catabolism
2-MethylCrotonyl CoA Carboxylase
Deficiency Symptoms
Neurological
Dermatitis
Egg White Injury Disease
Avidin binding decreases biotin status
Deficiency Diagnosis
Accumulation of holocarboxylase substrates + lactate
Intestinal Bacteria Synthesis
Production from food
Holocarboxylases
holocarboxylase synthase
Status
Contributions
