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Chapter 19 Lecture 2 (Folliculitis (Base of follicle becomes red, swollen,…

- - - - Toxins of both
        
        Leukocidin- Kills leukocytes giving staph additional protection against phagosis
        
        Epidermal cell differentiation inhibitor- protein that induces large holes in blood vessels
        
        Cytolytic toxins- Disrupts cell membrane
        
        Toxic shock syndrome- Proteins that cause SSSS
  - - - Staphylokinase
        
        Disolves blood clots, spreads staph
      - Lipase
        
        Digests lipids and sebum, providing the pathogen with food
      - Hyaluronidaze
        
        Breaks down hyaluronic acid, allows bacteria to spread
      - B-Lactamase
        
        Gives resistance to many beta-lactam antimicrobial drugs like PCN
      - Coagulase
        
        Clots blood, hides bacteria
    - - Both types avoid body's defense system to stop chemotaxis and phagocytosis by leukocytes
      - Makes a slime layer that can attach staph biofilms to surfaces of catheters, shunts, artificial heart valves, and synthetic joints
- - - - Mupirocin and diloxacillian
    - - No treatment