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Chapter 19 Lecture 3 (Epidemiology (Diagnosis, Treatment, and Prevention…
Chapter 19 Lecture 3
Epidemiology
Both Staph & Strep spread by person to person contact or via fomites (toys, clothing, bedding, towels, or hairbrushes)
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Diagnosis, Treatment, and Prevention
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Pus found in the blisters are filled with bacteria and WBC (this is what separates impetigo from SSSS)
Treatment oral and topical antimicrobials(mupirocin, oral clindamycin, doxycycline)and careful cleaning of infected areas
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Pathogenesis
No scarring because the epidermis is unaffected by the toxin. The body restores the lost epidermis within 7-10 days.
The blood carries these toxins from the site of infection throughout the body. This circulation of toxins in blood is called toxemia
Mortality (death) is rare but if one does die, it is from a secondary infection of skinless areas by yeast like Candida albicans or by a bacteria like Pseudomonas aerugionosa
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Epidemiology
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Diagnosis, Treatment, and Prevention
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Remember that the fluid in the blisters does not contain the S. aureus since the disease is mediated by toxins released from a sit of infection that could have started elsewhere in the body
Since lots of strains make β-lactamase, treatment will be IV drugs like semisynthetic nafcillin or oxacillin that do not let β-lactamase to bind (remember that β-lactamase deactivates many drugs in the PCN class)
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