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PBI 288 - Midterm (2) (Neurotransmitters (criterias (Produced in…
PBI 288
-
Midterm
(2)
Neurotransmitters
criterias
P
roduced in neurons
R
eleased when neuron is stimulated
F
ound in neurons
A
ct on post-synaptic receptors
F R A P
Acetylcholine
Nicotinic
NA+, Ca2+, K+
EPSP
Muscarinic
(G) protein
IPSP
EPSP
Dopamine
D1 Like
post-syn.
(G)-protein
I or EPSP
D2 Like
post/pre-syn
(G)-Protein
I or EPSP
Opiods
mu
(G) = K+ OUT
IPSP
delta
(G) = K+/Ca2+ OUT
IPSP
kappa
(G) = Ca2+ OUT
IPSP
Noradrenalin
Alpha1 +2
(G)-protein
IPSP
Adrenalin
Beta1 + 2
(G)-protein
EPSP
GABA
GABA - A
Cl- OUT
IPSP
GABA - B
(G) - protein
IPSP
Glutamate
NMDA
Ca2+/K+/Na+ IN
EPSP
KAINA
Na+ IN
EPSP
AMPA
Na+ IN
EPSP
MANY
(g)-protein
EPSP
Indolamines
MANY
(G)-protein
I or E
Psychopharmaco
Agonist
facilitates effect
Antagonist
Opposes effect
Drugs can affect
Production
+
NT
AG
-
NT
ANT
Storage
BLOCK transporters
-
NT
ANT
Release
Bind to transporter protein
Helps binding
AG
Not bind
ANT
Receptor interaction
Ag or ANT
Bind to receptors
Competitive
ON NT site
Non-competitive
Not on NT site
Inactivation
Binds to deactivation enzyme
+
NT
AG
Reuptake
Blocks reuptake transporter
+
NT
AG
Degradation
+
NT
AG
Deactivate NT destroyer enzyme
Pharmacodynamics
effective dose
Toxic dose
Lethal dose
Therapeutic Index