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REGUB Micro - STIs (i) (Syphilis (tertiary (CVD, neurosyphilis (e.g.…

- - - - antenatal testing = standard, to prevent congenital syphilis
  - - - rash commonly on palms + soles
      - lesions in mouth + genital area
      - CNS symptoms in 35%
  - - - specific (treponemal)
        
        EIA
        
        TPPA (particle agglutination test)
        
        immunoblot assay
      - non-specific (non treponemal reaginic abs - IgM + IgG)
        
        RPR
        
        not v good for dx, better for detecting response to tx
      - CSF serology
  - - - has maintained its efficacy
      - if allergic consider desensitisation
    - - like anaphylaxis
      - can be esp severe in elderly + those with pre-existing CVD