Immune System

Pathogens

Viruses

Types of Barriers

Bacteria

Fungi

Innate Immunity

Adaptive Immunity (Third Line of Defense)

First Line of Defense

Second Line of Defense

Skin & its Secretions (Protects External Boundaries)

Mucous Membranes (Protects Internal Boundaries)

Lymphocytes

Fever

Inflammatory Response

Antimicrobal Proteins

Antibodies

Memory Cells

Phagocytic Leukocytes

Protozoa Screen Shot 2021-01-11 at 10.16.59 PM

A prokaryote which divides by binary fission

Screen Shot 2021-01-11 at 10.17.57 PM Causes food poisoning, ear & eye infections, and other diseases such as cholera, diarrhea, and etc.

Aceullular, thus needs a host cell to carry out function of life such as reproduction. Can also hold both DNA & RNA. Evolves, mutates, and recombines rapidly.

Cause diseases such as the flu, HIV/AIDS, smallpox, measles common cold, herpes, ebola, and more. Screen Shot 2021-01-11 at 10.12.14 PM

A eukaryote that reproduces with sporesScreen Shot 2021-01-11 at 10.15.28 PM

Can cause athlete's foot, mold, ringworms, allergic reactions, respiratory problems, and more.

Simple parasites

Can cause diseases such as Malaria, Leishmaniasis, Toxoplasmosis, and more

Sticky mucus which traps invaders

pH which isn't favorable for pathogens

Lysozymes which are enzymes that break down pathogens

Natural organisms work as completive exclusion by non-harmful microbes

Skin is continuous, thus making it difficult to find an opening. It has several layers and is tough while also being dry. Its pH isn't favorable to pathogens and lysozyme which break down pathogens. Its natural organisms work as competitive exclusion by non-harmful microbes.

Methods of Transmission

Ingested/Swallowed

Animal Vectors

Direct Contact

Bodily Fluids

Blood Contact

Leukocytes (White Blood Cells)

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Phagocytes (aids lymphocytes)

Oesinophil (parasites)

Basophil (allergies)

Lymphocytes

B-cells

T-cells

Killer cells

Neutrophil (bacteria/fungi)

Antigen

Antibody

A molecule/substance often upon a virus/cell surface which leads antibodies to form

Produced by mainly by plasma cell, it is a large, globular, y-shaped protein which recognizes specific antigens to bind to them as an immune response. May cause inflammation

Human Immunodeficiency Virus is a retrovirus, which inserts its RNA into host cells, slowly attacks the immune system, making it harder for someone to fight off infections and diseases. At the moment there is no cure but there is treatment

AIDS is the last stage of HIV, where the body can no longer defend itself, possibly developing various diseases and maybe death.

Risk Factors in HIV transmission

Higher Risk: Blood-blood contact, sexual intercourse, oral sex

Lower Risk: Saliva/kissing, ingestion, childbirth, breastfeeding

ABO Blood Groups act to tell if certain antigens on red blood cells are present or not, leading to the four types of A,B, AB, & O.

Acquired Immunity

Active (Antibodies from Self)

Passive (Ready-made Antibodies)

Natural (Maternal Antibodies)

Artificial (Antibodies from other sources)

Natural (Exposure to infectious agent)

Artificial (Immunization)

Move using chemotaxis to respond to invasion with proteins from pathogen or phospholipids from damaged cells. During phagocytosis, they engulf the pathogen using endocytosis, break down the pathogen using lysozymes, and remove anything else.

Neutralization: its attachment halts any effects or entry points for toxins in cells. Also prevents viruses from invading cells and bacteria from functioning, and thus attacking cells

Opsonization: its attachment marks the pathogens so other immune cells can easily identify, find, engulf, and digest them.

Agglutination: antibodies attach to each other, which causes a clumping, enhancing the effects of the previous two functions.

Complement activation: antibodies attach leads to other components to attack the pathogen

Histamine

A small set of organic molecules produced by basophils, which release through circulation, and mast cells, found in connective tissue which release if stimulated by an infection. It heavily affects the body's immune response as it raises the capillaries' permeability to white blood cells and some proteins, permitting early pathogen engagement at the site of infection. They may cause inflammation/hives, itching, sneezing, watery eyes, or more. Categorized as an allergy and antihistamines work to as a drug to oppose the activity of histamine receptors.

Vaccines

Permits someone immunity to a disease without needing to have had it. Vaccines hold antigens as forms of either attenuated/inactivated viruses, weakened toxins, or subparts. Works to create a primary immune response, which creates memory cells that develop immunity, and a secondary immune response which is much faster and stronger in comparison. The vaccine should not typically cause symptoms in a healthy person and can be taken orally or injected

Antibiotics

A treatment drug that aids prokaryotic bacteria prevention which disrupts structure/metabolic pathways. They are ineffective against eukaryotic bacteria and viruses and using them in that context could lead to antibiotic resistance.

Monoclonal Antibodies

When an immune response gets stimulated with an antigen, antibodies are used therapeutically/diagnostically. Specific plasma B-cells are fused with a myeloma cell when the desired antibody are harvested, called hybridioma cells. After screening, selected ones aid in dividing for clones, making large quantities of single, multipurpose antibodies.

Blood Clotting works as a metabolic pathway which prevents blood loss and repairs tissue. Screen Shot 2021-01-11 at 10.08.13 PM

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