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Wound healing - Coggle Diagram
Wound healing
1)
Coagulation
Destruction
death of some epithelial and dermal cells
damage to collagenous fibres in tissue
small vessel rupture
increased vasodilation and permeability
release of blood into wound and coagulation
formation of fibrin clot
platelets and inflammatory cells
promote re-epithelialisation
platelet deposition and aggregation
platelet de-granulation
release PDGF, TGFb, fibronectin
2) inflammation
attraction/activation of infiltrating cells
leucocyte migration/influx
neutrophils
matrix phagocytosis and free radicals (infection)
monocytes/macrophages
removal of wound debris
phagocytosis
matrix degradation (collagenases, elastase)
major source of stimulatory signals/factors
lymphocytes
recruited later
important in the early remodelling phase