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Atopic dermatitis - Coggle Diagram
Atopic dermatitis
findings
starts around 1-3y of age
rare after 6y
sometimes presents <1y
should be responsive to high dose (1mg/kg/day) corticosteroids like prednisone
canine PE
feline PE
recurrent
rare
conjunctivitis
rhinitis
asthmas
secondary
infections
general
inflammatory
genetic predisposition
pruritic allergy
IgE Ab against environment allergens
pathogenesis
paticipating cells
Th2
Langerhans
abnormal skin barrier
Ceramide deficiency
a lipid forming intercellular lipid lamellae
"mortar"
fillagrin deficiency
give strength between skin cells
allergens
canine
house dust
house dust mites
molds
cat dander
feather
wool
most animals have AD year-round
pollen
feline
~half have year-round allergies
~40% seasonal/non-seasonal
1/5 react to pollen only
ddx
concurrent
food allergy
cannot be differentiated from AD
need food elimination trial
ruled out if there is seasonality
flea bite hypersensitivity
can present like sarcoptic mange
cheylletiosis
