Peningkatan laju napas, Hipertensi, Rickets, Disproporsional, Rasio BB/TB rendah, Frontal bossing, midfacial crowding, mikropenis, truncal obesity, Kulit kering dan kasar, wajah kasar, refleks menurun, goiter, bradikardia, makroglosia, Papiledema, defek lapangan pandang, Obesitas sentral, striae, hipertensi, hirsutism