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Microbiology (Staphylococci (Staph Aureus (Protein A (Binds Fc receptor of…
Microbiology
Staphylococci
Staph Aureus
Produces coagulase
Binds fibrinogen
Converts to fibrin
Golden - has carotenoid pigments
Most virulent form
Carried by 15% of people
Has a capsule
Inhibits chemotaxis + phagocytosis
Peptidoglycan layer
Techoic acid aids attachment to host
Via fibronectin receptors
Protein A
Binds Fc receptor of IgG1/2/4
Binds IgG Ab wrong way round = no longer works
Coats surface
Extracellular protein A
Forms immune complexes
Binds antibodies
Cytoplasmic membrane
Gram positive Cocci
No endospores
Spherical shape --> looks like a bunch of grapes
Non-motile
Facultatively anaerobic
grows with or without oxygen
Halo-tolerant
likes high % of salt
Found on skin + mucous membranes
Mesophyll
moderate temperature
Toxins
Alpha, Beta, Delta, Gamma, Leukocidin
Cytolytic
Membrane damaging toxins
Toxic to cells
Exfoliative toxin
Toxic shock syndrome Toxin 1
Extotoxins
A to E
Resistant to hydrolysis
Induce cytokine response
Enzymes
Catalase
conversion of toxic H2O2 to H20 + O2
Hyaluronidase
Breaks down hyaluronic acid in connective tissue
helps spread bacteria
TB
Bacillus
Pseudomonas
Curved gram negative organisms
Enteriobacteria
Pasteurella
Streptococci
Clostrida
Neisseria