When scar tissue replaces normal tissue. The scar tissue then blocks the flow of blood through the liver. No signs in the begining but towards the end, the patient begins to feel fatigue, nausea, weight loss, jaundice, itching, and swelling. 8-20%. Severe disorder. Hepatic fibrosis or cirrhosis. 4 stages- 1: Liver cell necrosis. 2: Inflammatory cell infiltrate. 3: Fibrosis. 4: Nodular regeneration which may be macronodular (alcohol), micronodular (viral), or mixed. Lab findings- Decreased albumin synthesis, increased PT, decreased cholesterol synthesis, elevated ammonia. Treatment depends on the reason. Alcoholics quit alcohol ect..
