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:star:Sulfonamides & Trimethoprim:star: UTI Infections (Treats (UTI…
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Sulfonamides & Trimethoprim:star:
UTI Infections
M.O.A.
Broad spectrum
BACTERIOSTATIC
SUPPRESS
bacterial growth by
INHIBITING FOLIC ACID
needed for DNA/RNA/ protein production
Once widely used , Now
LIMITED
Treats
BRONCHITIS
UTI IS MOST COMMON USE
Due to
EFFICACY ON
E.COLI
90% uti r/t
E.coli
OTITIS MEDIA
TRAVELERS DIARRHEA
ULCERATIVE COLITIS
PNEUMOCYSTIS CARINII PNEUMONIA
HIV/ opportunistic patients
BURN WOUND INFECTIONS
:star:**TOPICAL SILVER SULFADIAZINE
ADVERSE EFFECTS
photosensitivity
BLOOD DYSCRASIAS
hemolytic anemia/ agranulocytosis /leukopenia/ thrombocytopenia/ aplastic anemia
observe bleeding episodes/sore throat/pallor
Check pt and NOTIFY provider
get baseline
CBC
and monitor periodically
STEVENS JOHNSON SYNDROME
RASH THAT CAN BECOME WIDE SPREAD
OPENINGS AND OOZING
RESEMBLES NECROTIZING FASCITIS
dont give if allergic to sulfas
Thiazide diuretics / loop diuretics
STOP AT FIRST SIGN OF RASH
CRYSTALLURIA
Cristalline
aggregates in KIDNEYS/URETER/BLADDER
irritation and acute renal injury
2000-3000mL H20
monitor urine output
NAUSEA/VOMITING/DIARRHEA
KERNICTERUS
THIRD TRIMESTER brain damage most often seen in BBs
extreme buildup of
bilirubin in brain
, waster product of liver produced when
RBC
are broken down
DO NOT TAKE
3rd TRIMESTER
OR
BREASTFEEDING
Preparations
MEDIUM acting
rapid absorb + slow excrete
UTI/ EAR INFECTIONS
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TRIMETHOPRIM/SULFAMETHOXAZOLE:star:
(TMP/SMZ)
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SEPTRA:star:
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BACTRIM:star:
ULTRA LONG acting
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SULFAMYON CREAM:star:
MAY
cause metabolic acidosis is systemic
BURN CLIENTS
SHORT acting
rapid absorb + excrete
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SULFISOXAZOLE:star:
GANTRISON
COMMONLY USED URINARY ANTI-INFECTIVES
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NITROFURANTION MACROCRYTALS:star:
MACRODANTIN
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NITROFURANTOIN:star:
;FURADANTIN
D.O.C.
for
SUPPRESSING CHRONIC UTIS
bacterio
STATIC
CONTRAINDICATIONS
ANURIA
no urine
OLIGURIA
decreased urine
HYPERSENSITIVITY
sulfa/salcylates
NO
ASPIRIN
INCREASE TOXICITY
of sulfs by displacing from PBPS and reach toxic levels
FIRST TRIMESTER Newborns/Pregnant women
CATEGORY D
fetal defects
Nursing Implications
before administering
C&S
Hypersensitivity to sulfas / salcyltates
MONITOR
URINE
Urinalysis (Protein/WBC/gravity/color)
Urine for culture(what bacteria is in urine)
Urine sensitivity (which antibiotic you should use, most suseptible)
CBC
for low wbc
I&O
2000-3000mL or 8-10 glass per day H2O
teach about
blood disorders S&S
notify Md if any occur
avoid driving = dizziness
avoid direct sunlight