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:star:Clindamycin:star: (M.O.A. (Inhibits protein synthesis by BINDING to…
:star:Clindamycin:star:
M.O.A.
Inhibits protein synthesis
by
BINDING
to bacterial ribosomes
Active against most
anaerobic
bacteria that are
G+
BROAD SPECTRUM
G- & G+
ALT. to
penicillin
due to its efficacy toward
G+
BACTERIOSTATIC
OR
CIDAL
Interactions
OVERLAPPING OF BINDING SITES
=
ANTAGONISTIC EFFECT
The site at which :star:
Clindamycin
binds
OVERLAPS
those for :star:
ERYTHROMYCIN
and :star:
CHLORAMPHENICOL
Adverse effects
Suprainfection
Clostridum Dificle
AAPMC
TEACH PT
to report
SIGNIFICANT DIARRHEA WITH GREATER THAN 5 STOOLS A DAY
DISCONTINUE
:star:
CLINDAMYCIN
START
P.O.
:star:
VANCOMYCIN
:star:
METRONIDAZOLE;FLAGYL
FLUIDS AND ELECTROLYTES
DO NOT GIVE OPIOIDS
/
ANTICHOLERGENIC DRUGS
decrease motility/keep bacteria inside
Appearance of Sign & Symptoms
usually see during
1st
week of treatment
can last up to
4-6wks
after drug
withdrawn
Hypersensitivity
RARE
hepatoxicity/agranulocytis/leukopenia/thrombocytopenia
RAPID I.V.
CARDIOVASCULAR COLLAPSE
hypotension
and
DYSRYTHMIAS
Treats
Abdominal and Pelvic
infections
BACTERIOIDES FRAGILIS
CAUTION
resistance can be a problem
GROUP A STREPTOCOCCI
DRUG OF CHOICE
GAS GANGRENE
CLOSTRIDIUM PREFRINGENS