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:star:Linezolid:star:ZYVOX (FIVE approved indications to USE (complicated…
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Linezolid
:star:ZYVOX
M.O.A.
Member of new class:
Oxazolidinones
Works against
MULTI-DRUG RESISTANT
organisms
Should be
RESERVED
for these only
DOES NOT TREAT GRAM NEGATIVE G-
Treats
VANCOMYCIN-RESISTANT ENTEROCOCCUS
; VRE
MRSA
FIVE approved indications to
USE
Community associated PNEUMONIA
CAP
Caused by
STREP PNEUMONIAE
the PCN suseptible strands only
complicated skin and structure infections
Caused by
STAPH AUERUS
the methicillin susceptible and resistance strands
STREP PYOGENES
STREP ALGALACTAE
Health care-associated
pneumonia
Casue by
STAPH AUERUS
the methicillin susceptible and resistance strands
Uncomplicated skin and structure infections
STAPH AUREUS
STREP PYOGENES
Infections by
VRE
Adverse Effects
Well tolerated usually
Some Diarrhea and Headache
REVERSIBLE
Thrombo/anemia/leuko
Monitor CBC weekly
MYELOSUPPRESSION
anemia/leuko/thrombo/pancytopenia
Interactions
DRUG
INHIBITS MAO
DO NOT GIVE WITH MAO INHIBITORS
DO NOT GIVE WITH TYRAMINE FOODS
DO NOT GIVE WITH EPINEPHRINE/PSEUDOEPHEDRINE/COCAINE
HTN CRISIS
DRUG-DRUG
DO NOT TAKE WITH SSRI'S
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PAROXETINE;PAXIL :star:
DULOXETINE;CYMBALTA**
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LINEZOLID
is a WEAK INHIBITOR of MAO
INCREASES
serotonin content in CNS
Combined with adding SSRIs leads to
SERITONIN SYNDOME
can lead to
death
Nursing Implications
I.V. **SLOW 3-120 minutes
may need to be discontinued as treatment
P.O. may be taken with food
NO MAOS/SSRIS/TYRAMINE
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Chloramphenicol:star:
M.O.A
BROAD
spectrum
USE ONLY FOR
LIFE THREATENING INFECTIONS
for which safer drugs cannot be used
use
LOW
doses and monitor
CLOSELY
Treats
bacterial infections
adverse effects
FATAL SEVERE
BLOOD
disorders
GRAY SYNDROME
NEWBORNS
with toxic levels
ab distension
cyanosis
GRAY
skin tone