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:star:Tetracyclines:star: (Treats FIRST LINE (RICKETTSIAL DISEASES (Typhus…
:star:
Tetracyclines
:star:
M.O.A.
BACTERIOSTATIC
Suppress the growth but
DO NOT** kill
"second line agents"
BROAD SPECTRUM
Inhibitors of Protein synthesis by
INHIBITING RNA
No
CSF
Preparations
:star:
MINOCYCLINE
:star:
DEMECLOCYCLENE
:star:
TETRACYCLINE
:star:
DOXYCYCLINE
;VIBRAMYCIN
FIRST LINE
for
CHLAMYDIAL
P.O. not affected by food
LYME DISEASE
P.O. not affected by food
Treats
FIRST LINE
RICKETTSIAL DISEASES
Typhus fever
Q fever
Rocky mountain spotted fever
STDS
Chlamydia trachomatis
CHOLERA
PNEUMONIA
Mycoplasma pneumoniae
LYME DISEASE
Borriella burgdorferi
ACNE
TOPICALLY / P.O. for
acne vulgaris
PEPTIC ULCER DISEASE
Heilicobacter Pylori
COMBINE WITH :star:METRONIDAZOLE;FLAGYL
AND :star:
BISMUTH SUBSALICYLATE
;pepto bismol
Eradicates
PERIONDONTAL DISEASE
:star:
DOXYCYCLINE
;VIBRAMYCIN
P.O. OR TOPICALLY
Pharmacokinetics
Duration of action
INTERMEDIATE
:star:
DEMECLOCYCLINE
Moderate lipid solubility/60-80% P.O. absorption/
LARGE FOOD ABSORPTION DECREASE
/ RENAL
LONG
:star:
DOXYCYCLINE
HIGH
lipid solubility/90-100% P.O. absorption/
SMALL DECREASE
/ HEPATIC
:star:
MINOCYCLINE
HIGH
lipid solubility/90-100% P.O. absorption/
NO DECREASE
/ HEPATIC
SHORT
:star:
TETRACYCLINE
low lipid solubility/60-80% P.O. absorption/
LARGE FOOD ABSORPTION DECREASE
/ RENAL
ABSORPTION
DO NOT ADMINISTER DUE TO INSOLUBLE CHELATES
IRON
MAGNESIUM LAXATIVES
CALCIUM
milk
ANTI-ACIDS
distribution to almost all tissues
elimination
LONG
=hepatic
SHORT+INTER
=renal
Adverse effects
HEPATOXICITY
high doses lead to
liver disease
ESP in pregnant women AND post partum with kidney disease already
RENAL TOXICITY
Can build up in kidneys
suprainfections
Discoloration of
PERMANENT AND DECIDUOUS TEETH
DO NOT GIVE TO UNDER 8YRS OLD OR IN PREGNANCY
G.I.
irritation
Photosensitivity
Dose and administration
P.O/I.V./I.M.
1 hour
before meal
2 hours
after meal
Major Precautions
With the exception of :star:DOXYCYCLINE;VIBRAMYCIN
AND :star:MINOCYCLINE;MINOCIN
MONITOR RENAL CLOSELY
DIARRHEA
MAY INDICATE LIFE THREATENING
SUPRINFECTION
NOTIFY MD