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:star:Vancomycin:star: (M.O.A. (Although it inhibits cell wall…
:star:
Vancomycin
:star:
M.O.A.
DOES NOT HAVE BETA-LACTAM RING
Although it
inhibits
cell wall synthesis/lysis/death
DOES NOT INTERACT WITH PBPS
Instead;
BINDS to MOLECULE
that serve as
PRECURSORS FOR CELL WALL SYNTHESIS
Reserved for
Serious
infections only
Active only against
G+
Penicillin alternative
Potentially
TOXIC
most common hospital antibiotic
Insufficient for CSF
Treats
MRSA
Staph.auerus & epidermis
Especially those Methicillin resistant
Severe
Clostridium Difficle
IF
patient has
NOT
responded to :star:METRONIDIAZOL;FLAGYL
Pseudomembraneous Colitis
P.O.
Pharmacokinetics
absorption
I.V.
most common
MUST GIVE SLOW
60-90 min
G.I
is POOR ;
ONLY
when there is an infection in
INTESTINE
C-DIFF
Adverse Effects
OTOTOXICITY
Risk is
INCREASED
when
concurrent use with other ototoxic drugs
RENAL
impairment
Prolonged treatment
plasma levels EXCEED 30mcgs
RAPID INFUSION
RED MAN NECK SYNDROME
Flushing/Tachycardia/Urticaria
Renal failure Nephrotoxicity
MAJOR TOXICITY
To
minimize risk
TROUGH LEVELS TO BE 15-20mcg/dL
dependent on the
dose
and with other nephrotoxic drugs (
NSAIDS /AMINOGLYCOSIDES
)
If 50% increase in
serum creatinine
NEED TO DECREASE
thrombophlebitis
thrombocytopenia
Bleeding!!!
Nursing Implications
MUST
monitor blood levels for therapeutic trough levels
15-20mcg
PUMP
to diffuse 60-90 min
Monitor I.V. for thrombophlebitis
Contraindications
Use caution in those with
renal
and
hearing
issues
Evaluate effectiveness
fever reduction
WBC reduction
no adventitious breathing
pain relief
Do not give to those with
corn
allergy