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:star:Carbapenems:star: (M.O.A. (Preparations (:star: MEROPENEM, :star…
:star:
Carbapenems
:star:
M.O.A.
NEW
Beta-lactam Antibiotic
Very Broad spectrum
NONE
can treat MRSA
Preparations
:star:
MEROPENEM
:star:ERTAPENEM
:star:DORIPENEM
:star:
IMIPENEM
To delay
RESISTANCE
these should be
RESERVED
for pts who cannot be treated with a more
NARROW
agent
Treats
Serious Infections
SOME
meet
Pseudomonas
COMBINE WITH EXTENDED PCN: :star:PIPERICILLIN + TAZOBACTAM
(ZOSYN)
:star:
IMIPENEM
;PRIMAXIM
Beta-lactam/
BROADEST
of all spectrums most G- and G+
Treats
MIXED INFECTIONS
ANAEROBES
S.auerus
G-
Baccilli
Preparations
COMBINE WITH :star:CILASTIN
compound that inhibits
renal enzymes
of breaking down
imipenem
COMBINE WITH EXTENDED PCN: :star:PIPERICILLIN + TAZOBACTAM
(ZOSYN)
M.O.A.
Binds to
PBPS
and weakens cell wall
Can
PENETRATE
and
RESIST B-LACTAMASES
Pharmacokinetics
I.V ONLY
POOR
GI absorption
GOOD DISTRIUBTION
= into
CSF
RENAL ELIMINATION
MONITOR RENALS
Adverse Effects
GI
Nausea/vomiting/Diarrhea
MOST COMMON
Hypersensitivity
rash/pruitis/ drug fever
SUPRAINFECTIONS
Interactions
CAN REDUCE BLOOD LEVELS OF :star:
VALPROATE
;DEPAKOTE
used to control
SEIZURES
BREAKTHROUGH
seizures occur
Nursing Implications
PREGNANCY RISK
CATEGORY C
MONITOR RENALS