Systemic lupus erythematosus (SLE) (Treatment (NSAIDS, Disease-modifying…
Systemic lupus erythematosus (SLE)
Type III hypersensitivity. Autoimmune disease that causes inflammation.
Attack the body's cell membrane (autiphospholipid), cytoplasm (anticytoplasmic), and cell nucleus (antinuclear).
Exact trigger is unknown. Can be a genetic or familial factor(s) with hormonal and environmental influences.
Inability to recognize 'self'. Result in activation of B lymphocytes and cytotoxic T lymphocytes that will eventually lead to permanent organ damage.
Common organs affected are the skin, kidney, and musculoskeletal system.
Joint pain/swelling, skin rashes, fatigue, pericardial effusion (swelling, pleural effusion.
May developed a unique butterfly-shaped rash
Diagnostic Criteria. There are a total of 11 criterias, but four must be present to be diagnose with SLE
Skin: either have butterfly rash around the cheeks (malar), red raised discoid rash, or sensitivity to the sun (photosensitivity)
Ulcers around the mouth or nasopharynx
Arthritis at least two peripheral joints
Pleuritis or pericarditis
Proteinuria in urine 5g/dL or cellular cast from the kidney tubules
Anemia, leukopenia, or thrombocytopenia
Lab values for anti-DNA-antibody and anti-Sm
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Disease-modifying anti-rheumatoid drugs (DMARD)
antimalarial drug Plaquenil
Immunosuppressant drugs: cyclophosphamide, rituxamid, and mycophenolate