misleading assumption is that all participants respond to an intervention in the same way, no matter the context. In the real-world, people come to the treatment with different preconceived notions about what is wrong and what to do about it. Tension between “patient-centeredness” and application of an “evidence base”—between incorporating context and general applicability of evidence (“generalizability”)—keeps treatments that might be beneficial (e.g., depression treatment) from getting to people who could benefit from the treatments (e.g., persons with medical comorbidity such as diabetes who are sometimes poorly adherent to lifestyle changes and medical regimens; Ciechanowski, Katon, & Russo, 2000; Gonzalez et al., 2008). Mixed methods can offer insight into how an intervention works or does not work, and for whom and in what context.