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Sickle cell anemia (downstream causes (Kidney damage (Cardiovascular (Low…

- - - - Low blood pressure
      - Palpitations
      - Rapid heart beat
      - Weakness and and fatigue
    - - proteinuria, low absorption and filtration
  - - - Liver dysfinction, yellowing of body, jaundice
  - - - Liver defection,yellowing of body, jaundice
- - - - Direct cause
        
        Hemoglobin no oxygen, hemoglobin polimerization
        
        Clumped hemoglobin
        
        sickle cell shaped red blood cells
    - - Error in the DNA
      - Hemoglobin S are sensitive to low oxygen clump together and lead to tissue hypoxia
- - - - Aplastic crisis,splenic sequenstrationcrisis
- - - - Heart
      - Lungs
      - kidneys
      - Liver
      - Bones
      - Eyes
  - - - Nucleic acids
        
        DNA
        
        Nucleotides
        
        Adenine
        
        Guanine
        
        Thymine
        
        Cytosine
        
        RNA
        
        Nucleotides
        
        Adenine
        
        Guanine
        
        Cytosine
        
        Uracil
        
        mRNA
        
        tRNA
        
        rRNA
      - Lipids
        
        Fatty acids
      - Carbohydrates
        
        Sugar
    - - Quarternary structure
        
        Two or more polypeptide chains connected by
        intermolecular interactions
      - tertiary structure
        
        3 dimensional model due to
        intermolecular interactions
        between amino acids forming a
        polypeptide chain
      - Secondary structure
        
        Alpha helix, beta sheets and beta turns
      - Primary structure
        
        Sequence of amino acids