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Two parents have brought in their infant who has been diagnosed with…
Two parents have brought in their infant who has been diagnosed with circulatory problems and anemia (low red blood cell count). Upon microscopic examination, the infant’s blood cells look like red bananas. You recognize this as sickle cell disease, an inheritable condition caused by a single nucleotide “error” in the DNA. The mother tells you that her family has a history of sickle cell disease. This single error affects hemoglobin, the protein that carries oxygen in red blood cells. The parents ask you how a single mistake in the DNA could result in banana-shaped red blood cells.
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