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Synaptic Transmission I (Chemical Synapse (Neurotransmitters (peptides…
Synaptic Transmission I
Chemical Synapse
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Neurotransmitters
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Properties – depend on receptor neurotransmitter binds, not transmitter itself
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ATP
some chemical signaling through ATP –ATP is released through hemichannels – NO, CO traverse lipid bilayer through diffusion
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Electrical Synapse
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channels = low resistance, high conductance – depolarize postsynap cell
when depolarization > threshold, AP in postsynap cell
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Functional Significance
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2) developmental signaling – neighboring cells pass chemical & electrical signals needed for growth & development
3) control of circuity – i.e. retina, rods coupled to cone pathways in dim light
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Anatomical Debate
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with invention of micro-electrode & light microscope learned both electrical & chemical transmission